qt prolongation造句

• There have been post-marketing reports of drug interactions when erythromycin was coadministered with cisapride, resulting in QT prolongation, cardiac arrhythmias, ventricular tachycardia, ventricular fibrillation, and torsades de pointes, most likely due to the inhibition of hepatic metabolism of cisapride by erythromycin.
• For example, drugs with the potential to cause QT prolongation, including macrolide antibiotics ( telithromycin, erythromycin ), antiarrthymic drug ( amiodarone ), antidepressants ( imipramine, fluoxetine ) and antipsychotic drugs ( haloperidol, chlorpromazine ), also cause phospholipidosis in animal and human tissues.
• Abnormalities in conduction and repolarization of the heart that can result from anorexia nervosa include QT prolongation, increased heart muscle is a marker of the severity of the disease, and while it is reversible with treatment and refeeding, it is possible that it may cause permanent, microscopic changes to the heart muscle that increase the risk of sudden cardiac death.
• The last is in advanced stages ( Phase II clinical trial ) of a joint drug development by Vertex Pharmaceuticals's VX-680 ( Sausville, 234, last posted on 12 / 18 / 06 ) and Merck & Co ., although the Phase II clinical trial was suspended in November, 2007 due to QT prolongation observed in one patient in Phase I trial.
• A wide range of rare but potentially fatal side effects spontaneously reported to the U . S . FDA or the subject of case reports published in medical journals includes, but is not limited to, toxic epidermal necrolysis, Stevens-Johnson syndrome, heart arrhythmias ( " torsades de pointes " or QT prolongation ), allergic pneumonitis, bone marrow suppression, hepatitis or liver failure, and sensitivity to light.