1. From left to right : leadzyme, hammerhead ribozyme, twister ribozyme
  2. Leadzyme has been subjected to extensive biochemical and structural characterization.
  3. The minimal secondary structure of leadzyme is surprisingly very simple.
  4. Leadzyme is thought to perform catalysis using a two-step mechanism.
  5. However, in leadzyme this product is just an intermediate.
  6. It's difficult to find leadzyme in a sentence. 用leadzyme造句挺难的
  7. The leadzyme is thought to have a highly dynamic structure.
  8. This is also supported by the fact the reaction of the leadzyme is pH dependent.
  9. Examples of ribozymes include the hammerhead ribozyme, the VS ribozyme, Leadzyme and the hairpin ribozyme.
  10. They also showed that leadzyme motif is very common in the mRNA sequences of these organisms as well.
  11. This is shown in top figure on right, which is the secondary structure of leadzyme generated using mfold.
  12. Recently using time-resolved spectroscopy, it was shown that the active site of leadzyme is very dynamic.
  13. The crystal structure is consistent with a two-metal ion mechanism that has been proposed for leadzyme catalysis.
  14. In the ground state, leadzyme binds a single Sr 2 + ion at nucleotides G43, G45 and A45.
  15. The cleavage site of leadzyme is located within a four-nucleotide long asymmetric internal loop that also consists of RNA helices on its both sides.
  16. The structures of leadzyme have also been solved using X-ray crystallography and NMR . The crystal structures of the two conformations of leadzyme are shown in the lower figure on right.
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