glud1造句

• GLUD1 can form long fibers by end to end association of the hexamers.
• Alignment of GLUD1 from various sources, shows that the antenna probably evolved in the protista prior to the formation of purine regulatory sites.
• This suggests that there is some selective advantage of the antenna itself and that animals evolved new functions for GLUD1 through the addition of allosteric regulation.
• A comparison of the open and closed conformations of GLUD1 reveals changes in the small helix of the descending strand of the antenna, which seems to recoil as the catalytic cleft opens.
• The enzyme represents a key link between catabolic and GLUD1 ( glutamate dehydrogenase 1 ) and GLUD2 ( glutamate dehydrogenase 2 ), and there are also at least 8 GLDH pseudogenes in the human genome as well, probably reflecting microbial influences on eukaryote evolution.
• GLUD1 has two co-enzyme binding sites : one in the NAD-BD that is able to bind ether NAD + or NADP + and is directly involved in the catalytic process, and a second one, that has regulatory function, lying directly under the pivot helix, that can bind ADP, NAD +, or NADH, but does not bind NADPH well.