glud2造句

• The main functions of GluD2 in synaptic plasticity are carried out by its intracellular C-terminus.
• GluD2 induces synaptogenesis through interaction of its N-terminal domain with Cbln1, which in turn interacts with presynaptic neurexins, forming a bridge across cerebellar synapses.
• This is regulated by D-serine, which binds to the ligand-binding domain and results in changes in the structure of GluD2 without opening the channel.
• GluD2-containing receptors are selectively / predominantly expressed in Purkinje cells in the cerebellum where they play a key role in synaptogenesis, synaptic plasticity, and motor coordination.
• The enzyme represents a key link between catabolic and GLUD1 ( glutamate dehydrogenase 1 ) and GLUD2 ( glutamate dehydrogenase 2 ), and there are also at least 8 GLDH pseudogenes in the human genome as well, probably reflecting microbial influences on eukaryote evolution.